PJ 34 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 3255
Potent PARP inhibitor
Key Product Details
Description
Potent PARP inhibitor
Product Description
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide (Cat. No. 0788). Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo. Displays protective effects against cisplatin-induced kidney injury. Also displays activity at Pim-1 and Pim-2 kinases at higher concentrations (IC50 values are 3.7 and 16 μM respectively).Product Specifications
Molecular Weight
331.80
Formula
C17H17N3O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamide hydrochloride
CAS Number
344458-15-7
PubChem ID
16760621
InChI Key
RURAZZMDMNRXMI-UHFFFAOYSA-N
SMILES
Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.18 | 100 | |
| DMSO | 33.18 | 100 |
Preparing Stock Solutions
for PJ 34 hydrochloride
The following data is based on the product molecular weight 331.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
| 5 mM | 0.60 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.30 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.30 mL | 0.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Antolin Identification of Pim kinases as novel targets for PJ34 with confounding effects in PARP biology. ACS Chem.Biol. 2012 PMID: 23025350
- Gambi Poly(ADPR)polymerase inhibition and apoptosis induction in cDDP-treated human carcinoma cell lines. Biochem.Pharmacol. 2008 PMID: 18468580
- Kim Poly(ADP-ribose) polymerase 1 activation is required for cisp. nephrotoxicity. Kidney Int. 2012 PMID: 22437413
- Abdelkarim Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int.J.Mol.Med. 2001 PMID: 11179503
Product Specific Notices for PJ 34 hydrochloride
For research use only
Loading...
Loading...