Cisplatin
Tocris Bioscience, part of Bio-Techne | Catalog # 2251
Potent pro-apoptotic anticancer agent; activates caspase-3
Key Product Details
Description
Potent pro-apoptotic anticancer agent; activates caspase-3
Alternative Names
CDDP
Product Description
Cisplatin is a potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF-α-induced apoptosis.Product Specifications
Molecular Weight
300.05
Formula
Cl2H6N2Pt
Storage
Store at RT
Chemical Name
cis-Diaminodichloroplatinum
CAS Number
15663-27-1
PubChem ID
84691
InChI Key
LXZZYRPGZAFOLE-UHFFFAOYSA-L
SMILES
N.N.[Cl-].[Cl-].[Pt++]
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.5 | 5 with gentle warming |
Preparing Stock Solutions
for Cisplatin
The following data is based on the product molecular weight 300.05
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 66.66 mL | 333.28 mL | 666.56 mL |
| 0.25 mM | 13.33 mL | 66.66 mL | 133.31 mL |
| 0.5 mM | 6.67 mL | 33.33 mL | 66.66 mL |
| 2.5 mM | 1.33 mL | 6.67 mL | 13.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Duan Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisp. and tumor necrosis factor α. Clin.Cancer Res. 2004 PMID: 14734475
- Nomura Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells. Urol.Oncology
- Seki Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma. Cancer Chemother.Pharmacol. 2000 PMID: 10663637
Product Specific Notices for Cisplatin
For research use only
⚠ WARNING: This product can expose you to chemicals including Cisplatin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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