Phosphoramidon disodium salt

Name: Phosphoramidon disodium salt
Brand: Tocris Bioscience
SKU: 6333

Tocris Bioscience, part of Bio-Techne | Catalog # 6333

Citations (8)

COA / SDS

Neutral endopeptidase and endothelin converting enzyme inhibitor

Key Product Details

Description:	Neutral endopeptidase and endothelin converting enzyme inhibitor
Chemical Name:	N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt
Purity:	≥95% (HPLC)
Molecular Weight:	587.47

View Full Technical Details for Phosphoramidon disodium salt

Technical Data
Citations

Biological Activity for Phosphoramidon disodium salt

Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

Technical Data for Phosphoramidon disodium salt

M. Wt	587.47
Formula	C₂₃H₃₂N₃Na₂O₁₀P
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	164204-38-0
PubChem ID	16219931
InChi Key	OQKHVXFOYFBMDJ-ODIUWQMJSA-L
Smiles	CC(C[C@@H](C(N[C@H](C(O[Na])=O)CC1=CNC2=CC=CC=C12)=O)NP(O[C@@H]3O[C@H]([C@@H]([C@H]([C@H]3O)O)O)C)(O[Na])=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Phosphoramidon disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	58.75	100

Preparing Stock Solutions for Phosphoramidon disodium salt

The following data is based on the product molecular weight 587.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.70 mL	8.51 mL	17.02 mL
5 mM	0.34 mL	1.70 mL	3.40 mL
10 mM	0.17 mL	0.85 mL	1.70 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Phosphoramidon disodium salt

References are publications that support the biological activity of the product.

Shirotani Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J.Biol.Chem. 2001 PMID: 11278416
Warner Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA. Br.J.Pharmacol. 1992 PMID: 1393292
Marr and Hafez Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Front.Aging Neurosci. 2014 PMID: 25165447