PhiKan 083
Tocris Bioscience, part of Bio-Techne | Catalog # 4326
p53 stabilizing agent
Discontinued Product
4326 has been discontinued.
View all Additional p53-related Compounds products.
Product Description
PhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.Product Specifications
Molecular Weight
274.79
Formula
C16H18N2.HCl
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
CAS Number
1050480-30-2
PubChem ID
16255105
InChI Key
IXWVUPURFWFRNE-UHFFFAOYSA-N
SMILES
CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 13.74 | 50 | |
| DMSO | 27.48 | 100 |
Preparing Stock Solutions
for PhiKan 083
The following data is based on the product molecular weight 274.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.64 mL | 18.20 mL | 36.39 mL |
| 5 mM | 0.73 mL | 3.64 mL | 7.28 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.64 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wiman Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene. 2010 PMID: 20498645
- Boeckler Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc.Natl.Acad.Sci. 2008 PMID: 18650397
Product Specific Notices for PhiKan 083
For research use only
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