PFI 4
Tocris Bioscience, part of Bio-Techne | Catalog # 5576
Potent and selective BRPF1B bromodomain inhibitor
Discontinued Product
5576 has been discontinued.
View all Bromodomain Inhibitors products.
Key Product Details
Description
Potent and selective BRPF1B bromodomain inhibitor
Product Description
PFI 4 is a potent and selective BRPF1B bromodomain inhibitor (IC50 = 172 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of other bromodomains including BRPF2 (BRD1), BRPF3 and BRD4. Disrupts BRPF1 binding to histone H3.3. Cell permeable. Inhibits osteoclastogenesis.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the PFI 4 probe summary on the SGC website.Product Specifications
Molecular Weight
380.44
Formula
C21H24N4O3
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-pyrrolidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
CAS Number
900305-37-5
PubChem ID
40642506
InChI Key
QCIJLRJBZDBVDB-UHFFFAOYSA-N
SMILES
CN(C1=CC(NC(C2=C(OC)C=CC=C2)=O)=C(N3CCCC3)C=C1N4C)C4=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.02 | 50 | |
| Ethanol | 3.8 | 10 |
Preparing Stock Solutions
for PFI 4
The following data is based on the product molecular weight 380.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.26 mL | 26.29 mL | 52.57 mL |
| 2.5 mM | 1.05 mL | 5.26 mL | 10.51 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.05 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meier Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 2017 PMID: 28849908
- Demont 1,3-Dimethyl Benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 2014 PMID: 25408830
Product Specific Notices for PFI 4
For research use only
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