PF 670462

Name: PF 670462
Brand: Tocris Bioscience
SKU: 3316

Tocris Bioscience, part of Bio-Techne | Catalog # 3316

Citations (42)

COA / SDS

Potent and selective CK1ε and CK1δ inhibitor

Key Product Details

Description:	Potent and selective CK1ε and CK1δ inhibitor
Chemical Name:	4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	410.32

View Full Technical Details for PF 670462

Technical Data
Citations

Biological Activity for PF 670462

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC₅₀ values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC₅₀ = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

Compound Libraries for PF 670462

PF 670462 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PF 670462

M. Wt	410.32
Formula	C₁₉H₂₀FN₅.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	950912-80-8
PubChem ID	51049607
InChi Key	PSNKGVAXBSAHCH-UHFFFAOYSA-N
Smiles	NC1=NC=CC(C2=C(C4=CC=C(F)C=C4)N=CN2C3CCCCC3)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 670462

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.03	100

Preparing Stock Solutions for PF 670462

The following data is based on the product molecular weight 410.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.44 mL	12.19 mL	24.37 mL
5 mM	0.49 mL	2.44 mL	4.87 mL
10 mM	0.24 mL	1.22 mL	2.44 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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References for PF 670462

References are publications that support the biological activity of the product.

Bryant A role for casein kinase 1 epsilon in the locomotor stimulant response to metha. Psychopharmacology 2009 PMID: 19050854
Sprose Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys. Psychopharmacology 2009 PMID: 19277609
Badura An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditions. J.Pharmacol.Exp.Ther. 2007 PMID: 17502429