PF 670462

Tocris Bioscience, part of Bio-Techne | Catalog # 3316

Potent and selective CK1ε and CK1δ inhibitor
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Key Product Details

Description

Potent and selective CK1ε and CK1δ inhibitor

View all Casein Kinase 1 Inhibitors »

Product Description

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

Product Specifications

Molecular Weight

410.32

Formula

C19H20FN5.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

CAS Number

950912-80-8

PubChem ID

51049607

InChI Key

PSNKGVAXBSAHCH-UHFFFAOYSA-N

SMILES

NC1=NC=CC(C2=C(C4=CC=C(F)C=C4)N=CN2C3CCCCC3)=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.03 100

Preparing Stock Solutions for PF 670462

The following data is based on the product molecular weight 410.32

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.19 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 670462

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 670462

For research use only

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