PF 5006739
Tocris Bioscience, part of Bio-Techne | Catalog # 6346
Potent CK1δ/ε inhibitor
Product Description
PF 5006739 is a potent casein kinase 1δ/ε inhibitor (IC50 values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behavior in addiction in vivo models.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
419.46
Formula
C22H22FN7O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-[4-(4-Fluorophenyl)-1-[1-(3-isoxazolylmethyl)-4-piperidinyl]-1H-imidazol-5-yl]-2-pyrimidinamine
CAS Number
1293395-67-1
PubChem ID
51353555
InChI Key
XPWHRQHBPRSUAW-UHFFFAOYSA-N
SMILES
NC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.95 | 100 |
Preparing Stock Solutions
for PF 5006739
The following data is based on the product molecular weight 419.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wager Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 2014 PMID: 25299732
Product Specific Notices for PF 5006739
For research use only
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