pep2-EVKI

Name: pep2-EVKI
Brand: Tocris Bioscience
SKU: 1599

Tocris Bioscience, part of Bio-Techne | Catalog # 1599

Citations (7)

COA / SDS

Peptide inhibitor of GluA2 subunit binding to PICK1

Discontinued Product

1599 has been discontinued. View all AMPA Receptor Inhibitors products.

Technical Data
Citations & Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Peptide inhibitor of GluA2 subunit binding to PICK1

View all AMPA Receptor Inhibitors »

Product Description

pep2-EVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).

Product Specifications

Molecular Weight

1326.51

Formula

C₆₂H₉₅N₁₃O₁₉

Storage

Desiccate at -20°C

CAS Number

1315378-67-6

PubChem ID

90479809

InChI Key

KGQYILLVACJAQP-XMCCVONBSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in PBS (pH6.8)

Calculators

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Background References

References are publications that support the biological activity of the product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273
Hanley Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Neuron 2002 PMID: 11931741
Collingridge and Isaac Functional roles of protein interactions with AMPA and kainate receptors. Neurosci.Res. 2003 PMID: 12941441