Pep 2-8
Tocris Bioscience, part of Bio-Techne | Catalog # 6423
Potent PCSK9 inhibitor
Key Product Details
Description
Potent PCSK9 inhibitor
Product Description
Pep 2-8 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.Product Specifications
Molecular Weight
1715.88
Formula
C83H110N16O24
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
1541011-97-5
PubChem ID
124221781
InChI Key
ORPZALWAWWEEDP-NXXUBLNKSA-N
SMILES
CC(C)C[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in PBS (pH 7.4) |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 2014 PMID: 24225950
Product Specific Notices for Pep 2-8
For research use only
Loading...
Loading...