Ortho AP 1867

Name: Ortho AP 1867
Brand: Tocris Bioscience
SKU: 7787

Tocris Bioscience, part of Bio-Techne | Catalog # 7787

COA / SDS

Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

Key Product Details

Description:	Selective binding ligand for FKBP12^F36V; precursor for dTAG compounds
Chemical Name:	2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	693.79

View Full Technical Details for Ortho AP 1867

Technical Data
Citations

Biological Activity for Ortho AP 1867

Ortho AP 1867 is a selective binding ligand for the single point mutant of FKBP12^F36V. Functionalized with a carboxylic acid group in the ortho-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability. Ortho AP 1867 is a precursor for the dTAG compounds.

Technical Data for Ortho AP 1867

M. Wt	693.79
Formula	C₃₈H₄₇NO₁₁
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2230613-03-1
PubChem ID	133080821
InChi Key	UYXSZUBFOQLRNQ-BTIIJPOSSA-N
Smiles	CC[C@@H](C1=CC(OC)=C(C(OC)=C1)OC)C(N2CCCC[C@H]2C(O[C@@H](C3=CC=CC=C3OCC(O)=O)CCC4=CC(OC)=C(C=C4)OC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ortho AP 1867

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	69.38	100

Preparing Stock Solutions for Ortho AP 1867

The following data is based on the product molecular weight 693.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.44 mL	7.21 mL	14.41 mL
5 mM	0.29 mL	1.44 mL	2.88 mL
10 mM	0.14 mL	0.72 mL	1.44 mL
50 mM	0.03 mL	0.14 mL	0.29 mL

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References for Ortho AP 1867

References are publications that support the biological activity of the product.

Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585