OR-486

Name: OR-486
Brand: Tocris Bioscience
SKU: 0483

Tocris Bioscience, part of Bio-Techne | Catalog # 0483

Citations (24)

COA / SDS

COMT inhibitor

Key Product Details

Description:	COMT inhibitor
Chemical Name:	3,5-Dinitrocatechol
Purity:	≥99% (HPLC)
Molecular Weight:	200.11

View Full Technical Details for OR-486

Technical Data
Citations

Biological Activity for OR-486

OR-486 is a potent and selective inhibitor of catechol-O-methyl-transferase.

Technical Data for OR-486

M. Wt	200.11
Formula	C₆H₄N₂O₆
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	7659-29-2
PubChem ID	3870203
InChi Key	VDCDWNDTNSWDFJ-UHFFFAOYSA-N
Smiles	OC1=CC(=CC(=C1O)[N+]([O-])=O)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for OR-486

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	20.01	100
	DMSO	20.01	100

Preparing Stock Solutions for OR-486

The following data is based on the product molecular weight 200.11.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.00 mL	24.99 mL	49.97 mL
5 mM	1.00 mL	5.00 mL	9.99 mL
10 mM	0.50 mL	2.50 mL	5.00 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

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Reconstitution Calculator

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References for OR-486

References are publications that support the biological activity of the product.

Borgulya Catechol-O-methyltransferase-inhibiting pyrocatechol derivatives: synthesis and structure-activity studies. Helv.Chim.Acta
Mannisto and Kaakola Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease. Pharmacol.Toxicol. 1990 PMID: 2196554