OptoBI-1

Tocris Bioscience, part of Bio-Techne | Catalog # 7013

Photoswitchable TRPC3/6/7 agonist
Discontinued Product
7013 has been discontinued. View all TRPC Channel Activators products.

Key Product Details

Description

Photoswitchable TRPC3/6/7 agonist

View all TRPC Channel Activators »

Product Description

OptoBI-1 is a photoswitchable TRPC3/6/7 agonist (EC50 for active cis-form ~0.1 μM at TRPC3). Switches conformation from trans to cis at 365 nm and cis to trans at 430 nm. Returns to trans conformation in the dark after ~ 50 minutes. No effect observed on TRPC4 or 5. Rapidly changes TRPC3 conductance and inhibits neuronal firing in cis-state.

Product Specifications

Molecular Weight

523.67

Formula

C32H37N5O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[1-[4-[4-[(4-Butylphenyl)diazenyl]phenyl]butanoyl]piperidin-4-yl]-1,3-dihydro-2H-benzo[d]imidazol-2-one

CAS Number

2415272-11-4

InChI Key

LUASQYYRQCWOMA-XAHDOWKMSA-N

SMILES

CCCCC1=CC=C(/N=N/C2=CC=C(C=C2)CCCC(N3CCC(N4C(NC5=CC=CC=C45)=O)CC3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.24 10

Preparing Stock Solutions for OptoBI-1

The following data is based on the product molecular weight 523.67

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.10 mL 95.48 mL 190.96 mL
0.5 mM 3.82 mL 19.10 mL 38.19 mL
1 mM 1.91 mL 9.55 mL 19.10 mL
5 mM 0.38 mL 1.91 mL 3.82 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for OptoBI-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for OptoBI-1

For research use only

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