Oltipraz

Tocris Bioscience, part of Bio-Techne | Catalog # 5294

Nrf2 activator
Discontinued Product
5294 has been discontinued. View all Nrf2 Activators products.

Key Product Details

Description

Nrf2 activator

View all Nrf2 Activators »

Product Description

Oltipraz is a Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

Product Specifications

Molecular Weight

226.34

Formula

C8H6N2S3

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione

CAS Number

64224-21-1

PubChem ID

47318

InChI Key

CKNAQFVBEHDJQV-UHFFFAOYSA-N

SMILES

CC1=C(SSC1=S)C2=CN=CC=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.32 50

Preparing Stock Solutions for Oltipraz

The following data is based on the product molecular weight 226.34

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.84 mL 44.18 mL 88.36 mL
2.5 mM 1.77 mL 8.84 mL 17.67 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
25 mM 0.18 mL 0.88 mL 1.77 mL

Calculators

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Oltipraz

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Oltipraz

For research use only

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