NQDI 1
Tocris Bioscience, part of Bio-Techne | Catalog # 4429
ASK1 inhibitor
Discontinued Product
4429 has been discontinued.
View all ASK1 Inhibitors products.
Product Description
NQDI 1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).Product Specifications
Molecular Weight
319.31
Formula
C19H13NO4
Storage
Store at +4°C
Purity
≥99% (HPLC)
Chemical Name
2,7-Dihydro-2,7-dioxo-3H-naphtho[1,2,3-de]quinoline-1-carboxylic acid ethyl ester
CAS Number
175026-96-7
PubChem ID
5522952
InChI Key
UFJGFNHRMPMALC-UHFFFAOYSA-N
SMILES
O=C2NC1=CC=CC4=C1C(C3=CC=CC=C3C4=O)=C2C(OCC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.19 | 10 |
Preparing Stock Solutions
for NQDI 1
The following data is based on the product molecular weight 319.31
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.32 mL | 156.59 mL | 313.18 mL |
| 0.5 mM | 6.26 mL | 31.32 mL | 62.64 mL |
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Volynets Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1). J.Med.Chem. 2011 PMID: 21449566
- Bu Synthesis and cytotoxic activity of 7-oxo-7H-dibenz[f,ij]isoquinoline and 7-oxo-7H-benzo[e]perimidine derivatives. J.Med.Chem. 2001 PMID: 11384245
Product Specific Notices for NQDI 1
For research use only
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