Nor NOHA monoacetate
Tocris Bioscience, part of Bio-Techne | Catalog # 6370
Arginase inhibitor
Product Description
Nor NOHA monoacetate is a reversible, competitive arginase inhibitor (IC50 = 2 μM). Exhibits 10-fold selectivity for human type II arginase over type I. Enhances the effect of acetylcholine on isolated aortic and mesenteric arterial rings. Inhibits growth of lung carcinoma implants in mice.Product Specifications
Molecular Weight
236.23
Formula
C5H12N4O3.C2H4O2
Storage
Store at -20°C
Chemical Name
(2S)-2-Amino-4-[[(hydroxyamino)iminomethyl]amino]butanoic acid monoacetate
CAS Number
2250019-93-1
PubChem ID
131648256
InChI Key
RYUGHGOGNIYFKU-DFWYDOINSA-N
SMILES
N[C@@H](CCNC(NO)=N)C(O)=O.O=C(O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.62 | 100 |
Preparing Stock Solutions
for Nor NOHA monoacetate
The following data is based on the product molecular weight 236.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.23 mL | 21.17 mL | 42.33 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.47 mL |
| 10 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.85 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rodriguez Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 2004 PMID: 15313928
- Colleluori and Ash Classical and slow-binding inhibitors of human type II arginase. Biochemistry 2001 PMID: 11478904
- Huynh The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br.J.Pharmacol. 2009 PMID: 19133993
- Custot The new α-amino acid Nω-hydroxy-nor-L-arginine: a high affinity inhibitor of arginase well adapted to bind to its manganese cluster. J.Am.Chem.Soc.
Product Specific Notices for Nor NOHA monoacetate
For research use only
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