[Nle⁴,D-Phe⁷]-α-MSH

Name: [Nle 4 ,D-Phe 7 ]- α -MSH
Brand: Tocris Bioscience
SKU: 3013

Tocris Bioscience, part of Bio-Techne | Catalog # 3013

Citations (9)

COA / SDS

Melanocortin receptor agonist

Key Product Details

Description:	Melanocortin receptor agonist
Alternative Names:	Melanotan I,MT-I,NDP-α-MSH
Purity:	≥95% (HPLC)
Molecular Weight:	1646.86

View Full Technical Details for [Nle⁴,D-Phe⁷]-α-MSH

Technical Data
Citations

Biological Activity

[Nle⁴,D-Phe⁷]-α-MSH is a synthetic analog of α-MSH that is an agonist at melanocortin receptors (K_i values are 0.085, 0.4, 3.8 and 5.1 nM for MC₁, MC₃, MC₄ and MC₅ receptors respectively).

Technical Data

M. Wt	1646.86
Formula	C₇₈H₁₁₁N₂₁O₁₉
Single Letter Sequence	SYSXEHFRWGKPV (Modifications: Ser-1 = N-terminal Ac, X = Nle, Phe-7 = D-Phe, Val-13 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	75921-69-6
PubChem ID	16132139
InChi Key	UAHFGYDRQSXQEB-PWPYQVNISA-N
Smiles	CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

Soluble to 0.6mg/ml in water

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References

References are publications that support the biological activity of the product.

Sawyer 4-Norleucine, 7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultrapotent biological activity. Proc.Natl.Acad.Sci.USA
Wikber Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 1999 PMID: 10443584

[Nle⁴,D-Phe⁷]-α-MSH

Tocris Bioscience, part of Bio-Techne | Catalog # 3013

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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[Nle4,D-Phe7]-α-MSH

Tocris Bioscience, part of Bio-Techne | Catalog # 3013

Key Product Details

Biological Activity

Technical Data

Solubility

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

[Nle⁴,D-Phe⁷]-α-MSH