NICE 01
Tocris Bioscience, part of Bio-Techne | Catalog # 8088
Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
Key Product Details
Description
Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
Product Description
NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.Product Specifications
Molecular Weight
1206.85
Formula
C63H76ClN7O13S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
CAS Number
2982819-94-1
PubChem ID
169183208
InChI Key
USCBOLCYUGPYAF-YUZLDYPQSA-N
SMILES
O=C(O[C@H](CCC1=CC=C(C(OC)=C1)OC)C2=CC=CC(OCC(NCCOCCOCCNC(C[C@H]3C4=NN=C(N4C5=C(C(C6=CC=C(C=C6)Cl)=N3)C(C)=C(S5)C)C)=O)=O)=C2)[C@H]7N(CCCC7)C([C@@H](CC)C8=CC(OC)=C(C(OC)=C8)OC)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.34 | 50 |
Preparing Stock Solutions
for NICE 01
The following data is based on the product molecular weight 1206.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 1.66 mL | 8.29 mL | 16.57 mL |
| 2.5 mM | 0.33 mL | 1.66 mL | 3.31 mL |
| 5 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 25 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Gibson Bifunctional small molecules that induce nuclear localization and targeted transcriptional regulation. J.Am.Chem.Soc. 2023 PMID: 37461636
- Lu Bioorthogonal chemical epigenetic modifiers enable dose-dependent CRISPR targeted gene activation in mammalian cells. A.C.S.Synth.Biol. 2022 PMID: 35302756
Product Specific Notices for NICE 01
For research use only
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