NF 1819

Name: NF 1819
Brand: Tocris Bioscience
SKU: 5956

Tocris Bioscience, part of Bio-Techne | Catalog # 5956

COA / SDS

Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant

Discontinued Product

5956 has been discontinued. View all Monoacylglycerol Lipase Inhibitors products.

Key Product Details

Description:	Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant
Chemical Name:	(3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone
Purity:	≥98% (HPLC)
Molecular Weight:	463.46

View Full Technical Details for NF 1819

Technical Data
Citations

Biological Activity for NF 1819

NF 1819 is a potent and selective irreversible MAGL inhibitor (IC₅₀ values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively). Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC₅₀ > 10 μM). Alleviates symptoms in a MS in vivo model. Exhibits analgesic effects in an acute inflammatory pain model in vivo. Ameliorates neuropathic hypersensitivity induced by oxaliplatin (Cat. No. 2623). Displays high membrane permeability and brain penetrant.

Technical Data for NF 1819

M. Wt	463.46
Formula	C₂₄H₂₂FN₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1881244-28-5
PubChem ID	127032456
InChi Key	XRIROGBLGLPXQI-FGZHOGPDSA-N
Smiles	FC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NF 1819

References are publications that support the biological activity of the product.

Brindisi Development and pharmacological characterization of selective blockers of 2-arachidonoyl glycerol degradation with efficacy in rodent models of multiple sclerosis and pain. J.Med.Chem. 20106 PMID: 26888301

NF 1819

Tocris Bioscience, part of Bio-Techne | Catalog # 5956

Key Product Details

Biological Activity for NF 1819

Technical Data for NF 1819

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for NF 1819

Product Documents for NF 1819

COA

Certificate of Analysis

SDS

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