NF 1819
Tocris Bioscience, part of Bio-Techne | Catalog # 5956
Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant
Discontinued Product
5956 has been discontinued.
View all Monoacylglycerol Lipase Inhibitors products.
Key Product Details
Description
Potent and selective irreversible MAGL inhibitor; membrane permeable and brain penetrant
Product Description
NF 1819 is a potent and selective irreversible MAGL inhibitor (IC50 values are 0.25 and 7.4 nM at rMAGL and hMAGL, respectively). Exhibits 389-fold selectivity over hFAAH and exhibits minimal binding at CB receptors (IC50 > 10 μM). Alleviates symptoms in a MS in vivo model. Exhibits analgesic effects in an acute inflammatory pain model in vivo. Ameliorates neuropathic hypersensitivity induced by oxaliplatin (Cat. No. 2623). Displays high membrane permeability and brain penetrant.Product Specifications
Molecular Weight
463.46
Formula
C24H22FN5O4
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(3R,4S)-rel-4-(1,3-Benzodioxol-5-yl)-3-(4-fluorophenyl)-1-[1-(1H)-1,2,4-triazol-1-carbonyl)-4-piperidinyl]-2-azetidinone
CAS Number
1881244-28-5
PubChem ID
127032456
InChI Key
XRIROGBLGLPXQI-FGZHOGPDSA-N
SMILES
FC1=CC=C([C@@H]2[C@@H](C3=CC=C4OCOC4=C3)N(C2=O)C5CCN(C(N6C=NC=N6)=O)CC5)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.35 | 100 | |
| Ethanol | 23.17 | 50 |
Preparing Stock Solutions
for NF 1819
The following data is based on the product molecular weight 463.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.16 mL | 10.79 mL | 21.58 mL |
| 5 mM | 0.43 mL | 2.16 mL | 4.32 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.16 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for NF 1819
For research use only
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