NDT 30805
Tocris Bioscience, part of Bio-Techne | Catalog # 7808
Potent NLRP3 inflammasome inhibitor
Key Product Details
Description
Potent NLRP3 inflammasome inhibitor
Product Description
NDT 30805 is a potent NLRP3 inflammasome inhibitor. Inhibits IL-1β release in peripheral blood mononuclear cell assay, ASC speck assay and in whole blood (IC50 values are 13 nM, 34 nM and 1500 nM). Inhibits Nigericin (Cat. No. 4312) and ATP-induced IL-1β release. Soluble and uncharged at physiological pH.Product Specifications
Molecular Weight
414.53
Formula
C23H22N6S
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione
PubChem ID
164946940
InChI Key
BHTLYBBOAZYXBF-UHFFFAOYSA-N
SMILES
S=C(C=C(CC1=NC=CC=C1)N2)N(C2=N3)N=C3NC4=C5C(CCC5)=CC6=C4CCC6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.45 | 100 |
Preparing Stock Solutions
for NDT 30805
The following data is based on the product molecular weight 414.53
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.06 mL | 24.12 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Harrison Discovery and optimization of triazolopyrimidinone derivatives as selective NLRP3 inflammasome inhibitors. ACS Med.Chem.Lett. 2022 PMID: 35978696
Product Specific Notices for NDT 30805
For research use only
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