N1,N11-Diethylnorspermine tetrahydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 0468
Spermine and spermidine acetyltransferase potentiator
Key Product Details
Description
Spermine and spermidine acetyltransferase potentiator
Product Description
N1,N11-Diethylnorspermine tetrahydrochloride is a highly potent inducer of spermidine/spermine N1-acetyltransferase, able to increase enzyme activity 200-1000 fold.Product Specifications
Molecular Weight
390.27
Formula
C13H32N4.4HCl
Storage
Store at RT
Chemical Name
N,N'-bis[3-(Ethylamino)propyl]-1,3-propanediamine tetrahydrochloride
CAS Number
156886-85-0
PubChem ID
11501988
InChI Key
LAWBSOKBIROCQP-UHFFFAOYSA-N
SMILES
CCNCCCNCCCNCCCNCC.Cl.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 39.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 390.27
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.56 mL | 12.81 mL | 25.62 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.12 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Porter Antitumour activity of N1,N12-bis(ethyl)-norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 1993 PMID: 8425191
- Fogel-Petrovic Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs. Mol.Pharmacol. 1997 PMID: 9224814
- Libby Characterization of human spermidine spermine N1-acetyltransferase purified from cultured melanoma cells. Arch.Biochem.Biophys. 1991 PMID: 1989509
- Bernacki Antitumour activity of N1,N12-bis(ethyl)spermine homologs against human MALME-3 melanoma xenografts. Cancer Res. 1992 PMID: 1568212
Product Specific Notices
For research use only
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