MS 28
Tocris Bioscience, part of Bio-Techne | Catalog # 8076
Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)
Key Product Details
Description
Cyclin D1, CDK4/6 and cyclin D3 Degrader (PROTAC®)
Product Description
MS 28 is a cyclinD1 Degrader (PROTAC®) (DC50 = 950 nM; Dmax = 90% in vitro). Also degrades CDK4, CDK6 and cyclin D3 after 4 hours. Degrades cyclin D1 and cyclin D3 by recruiting the CDK4/6 as a 'bridge'. Comprises a CDK4/6 binding moiety joined by a linker to a VHL ligand. Suppresses NCI-H2110 and Calu-1 cancer cell growth at 1 μM.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from Icahn School of Medicine at Mount Sinai.Product Specifications
Molecular Weight
1002.25
Formula
C53H67N11O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S,4R)-1-((S)-2-(7-(4-(6-((6-Acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2229974-73-4
PubChem ID
146014438
InChI Key
MWVNDEBEHBRZEC-WWTLGBROSA-N
SMILES
O=C1N(C2CCCC2)C3=NC(NC4=CC=C(N5CCN(CC5)C(CCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)=O)=O)=O)C=N4)=NC=C3C(C)=C1C(C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100.22 | 100 |
Preparing Stock Solutions
for MS 28
The following data is based on the product molecular weight 1002.25
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.00 mL | 4.99 mL | 9.98 mL |
| 5 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 10 mM | 0.10 mL | 0.50 mL | 1.00 mL |
| 50 mM | 0.02 mL | 0.10 mL | 0.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Xiong Bridged proteolysis targeting chimera (PROTAC) enables degradation of undruggable targets. J.Am.Chem.Soc. 2022 PMID: 36448571
Product Specific Notices for MS 28
For research use only
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