MRS 1754
Tocris Bioscience, part of Bio-Techne | Catalog # 2752
Selective A2B antagonist
Key Product Details
Description
Selective A2B antagonist
Product Description
MRS 1754 is a selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).Licensing Information
Sold with the permission of the University of Virginia Patent FoundationProduct Specifications
Molecular Weight
486.52
Formula
C26H26N6O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
CAS Number
264622-58-4
PubChem ID
6603931
InChI Key
AJBBEYXFRYFVNM-UHFFFAOYSA-N
SMILES
CCCN1C2=C(NC(=N2)C2=CC=C(OCC(=O)NC3=CC=C(C=C3)C#N)C=C2)C(=O)N(CCC)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.43 | 5 with gentle warming |
Preparing Stock Solutions
for MRS 1754
The following data is based on the product molecular weight 486.52
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 41.11 mL | 205.54 mL | 411.08 mL |
| 0.25 mM | 8.22 mL | 41.11 mL | 82.22 mL |
| 0.5 mM | 4.11 mL | 20.55 mL | 41.11 mL |
| 2.5 mM | 0.82 mL | 4.11 mL | 8.22 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ji [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors. Biochem.Pharmacol. 2001 PMID: 11266650
- Nemeth Adenosine receptor activation ameliorates type I diabetes. FASEB J.
- Kim Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 2000 PMID: 10737749
Product Specific Notices for MRS 1754
For research use only
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