ML 298 hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 4895
Selective PLD2 inhibitor
Discontinued Product
4895 has been discontinued.
View all Phospholipase Inhibitors products.
Product Description
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively). Decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability.Product Specifications
Molecular Weight
468.90
Formula
C22H23F3N4O2.HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride
PubChem ID
78243721
InChI Key
GMGMJMDCWRCPHP-UHFFFAOYSA-N
SMILES
O=C(NCCN2CCC(C(NCN3C4=CC(F)=CC=C4)=O)3CC2)C1=CC=C(F)C(F)=C1.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 11.72 | 25 |
Preparing Stock Solutions
for ML 298 hydrochloride
The following data is based on the product molecular weight 468.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.53 mL | 42.65 mL | 85.31 mL |
| 1.25 mM | 1.71 mL | 8.53 mL | 17.06 mL |
| 2.5 mM | 0.85 mL | 4.27 mL | 8.53 mL |
| 12.5 mM | 0.17 mL | 0.85 mL | 1.71 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for ML 298 hydrochloride
For research use only
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