ML 233
Tocris Bioscience, part of Bio-Techne | Catalog # 5966
Non-peptide apelin agonist
Product Description
ML 233 is a non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).Product Specifications
Molecular Weight
359.44
Formula
C19H21NO4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one
CAS Number
2080311-92-6
PubChem ID
60138111
InChI Key
RSMZOLWJZGIWOV-CZIZESTLSA-N
SMILES
CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.97 | 50 |
Preparing Stock Solutions
for ML 233
The following data is based on the product molecular weight 359.44
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.56 mL | 27.82 mL | 55.64 mL |
| 2.5 mM | 1.11 mL | 5.56 mL | 11.13 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 25 mM | 0.11 mL | 0.56 mL | 1.11 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Khan Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program 2011 PMID: 22834038
- Yang Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 2015 PMID: 26143239
Product Specific Notices for ML 233
For research use only
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