Mitoxantrone dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4250

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent
Discontinued Product
4250 has been discontinued. View all DNA Topoisomerase Inhibitors products.

Key Product Details

Description

Topoisomerase II inhibitor; immunosuppressive and antineoplastic agent

View all DNA Topoisomerase Inhibitors »

Product Description

Mitoxantrone dihydrochloride is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2.

Product Specifications

Molecular Weight

517.40

Formula

C22H28N4O6.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride

CAS Number

70476-82-3

PubChem ID

51082

InChI Key

ZAHQPTJLOCWVPG-UHFFFAOYSA-N

SMILES

O=C2C3=C(C(O)=CC=C3O)C(C1=C(NCCNCCO)C=CC(NCCNCCO)=C12)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.59 5
DMSO 38.8 75

Preparing Stock Solutions for Mitoxantrone dihydrochloride

The following data is based on the product molecular weight 517.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 2.58 mL 12.88 mL 25.77 mL
3.75 mM 0.52 mL 2.58 mL 5.15 mL
7.5 mM 0.26 mL 1.29 mL 2.58 mL
37.5 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Mitoxantrone dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Mitoxantrone dihydrochloride

For research use only

⚠ WARNING: This product can expose you to chemicals including Mitoxantrone hydrochloride, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov
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