8 results for "DNA Topoisomerase Inhibitors" in Products
DNA Topoisomerase Inhibitors Products
Topoisomerases are ubiquitously expressed enzymes that overcome topological problems in genomic DNA, which can result from DNA replication, transcription and repair. Common problems such as overwinding (positive supercoiling), knots and tangles are resolved by topoisomerases by catalyzing the breaking of one or two strands of DNA.
Topoisomerase type I enzymes cut just one strand of the DNA double helix, and therefore relax supercoiling of the DNA. Four genes encode Type I topoisomerases, which ...
DNA topoisomerase inhibitor
| Chemical Name: | (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Purity: | ≥98% (HPLC) |
Antitumor antibiotic agent. Inhibits DNA topoisomerase II
| Alternate Names: | Adriamycin,NSC 123127 |
| Chemical Name: | 10-[(3-Amino-2,3,6-trideoxy-α-L-lyxohexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-5,12-naphthacenedione hydrochloride |
| Purity: | ≥98% (HPLC) |
DNA topoisomerase I inhibitor; antitumor
| Alternate Names: | 7-Ethyl-10-hydroxycamptothecin |
| Chemical Name: | (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione |
| Purity: | ≥98% (HPLC) |
DNA topoisomerase I inhibitor; antitumor
| Alternate Names: | Irinotecan,Camptothecin 11 |
| Chemical Name: | (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride |
| Purity: | ≥98% (HPLC) |
Topoisomerase II inhibitor
| Chemical Name: | [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one |
| Purity: | ≥98% (HPLC) |
Topoisomerase II inhibitor
| Alternate Names: | ICRF-187 |
| Chemical Name: | 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione hydrochloride |
| Purity: | ≥98% (HPLC) |
Antibiotic; inhibits bacterial DNA synthesis
| Alternate Names: | CP 99219 |
| Chemical Name: | 7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate |
| Purity: | ≥98% (HPLC) |
Inhibits TNF-α-induced NF-κB activation
| Chemical Name: | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
| Purity: | ≥98% (HPLC) |
