MC 1742
Tocris Bioscience, part of Bio-Techne | Catalog # 5727
Potent class I and IIb HDAC inhibitor
Key Product Details
Description
Potent class I and IIb HDAC inhibitor
Product Description
MC 1742 is a potent class I and IIb HDAC inhibitor (IC50 values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM .Product Specifications
Molecular Weight
395.47
Formula
C21H21N3O3S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
CAS Number
1776116-74-5
PubChem ID
49769453
InChI Key
AOFVDNFTELWRHV-UHFFFAOYSA-N
SMILES
O=C(NC(SCCCCC(NO)=O)=N1)C=C1C(C=C2)=CC=C2C3=CC=CC=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.55 | 100 |
Preparing Stock Solutions
for MC 1742
The following data is based on the product molecular weight 395.47
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.64 mL | 25.29 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
| 10 mM | 0.25 mL | 1.26 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mai Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. Bioorg.Med.Chem.Lett. 2008 PMID: 18381238
- Mai Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J.Med.Chem. 2006 PMID: 17004718
- Di Pompo Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J.Med.Chem. 2015 PMID: 25905694
Product Specific Notices for MC 1742
For research use only
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