[Lys⁵,MeLeu⁹,Nle¹⁰]-NKA(4-10)

Name: [Lys 5 ,MeLeu 9 ,Nle 10 ]-NKA(4-10)
Brand: Tocris Bioscience
SKU: 3228

Tocris Bioscience, part of Bio-Techne | Catalog # 3228

COA / SDS

Selective NK2 agonist

Discontinued Product

3228 has been discontinued. View all NK2 Receptor Agonists products.

Key Product Details

Description:	Selective NK₂ agonist
Molecular Weight:	804

View Full Technical Details for [Lys⁵,MeLeu⁹,Nle¹⁰]-NKA(4-10)

Technical Data
Citations

Biological Activity

Highy selective and potent NK₂ receptor agonist (IC₅₀ = 6.1 nM). Induces contraction of the rat fundus and bladder (EC₅₀ values are 117 and 10 nM respectively).

Technical Data

M. Wt	804
Formula	C₃₉H₆₅N₉O₉
Single Letter Sequence	DKFVGLX (Modifications: Leu-6 = Leu(N-methyl), X = Nle & C-terminal amide)
Storage	Desiccate at -20°C
CAS Number	137565-28-7
PubChem ID	10417908
InChi Key	FIBMQAYBIOYAKI-HLYNNXGTSA-N
Smiles	[H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References

References are publications that support the biological activity of the product.

Matuszek An investigation of tachykinin NK₂ receptor subtypes in the rat. Eur.J.Pharmacol. 1998 PMID: 9718274
Burcher Tachykinin NK₂ receptor and functional mechanisms in human colon: changes with indomet. and in diverticular disease and ulcerative colitis. J.Pharmacol.Exp.Ther. 2008 PMID: 17959748
Chassaing Selective agonists of NK-2 binding sites highly active on rat portal vein (NK-3 bioassay). Neuropeptides 1991 PMID: 1658676

[Lys⁵,MeLeu⁹,Nle¹⁰]-NKA(4-10)

Tocris Bioscience, part of Bio-Techne | Catalog # 3228

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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[Lys5,MeLeu9,Nle10]-NKA(4-10)

Tocris Bioscience, part of Bio-Techne | Catalog # 3228

Key Product Details

Biological Activity

Technical Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References

Product Documents

COA

Certificate of Analysis

SDS

[Lys⁵,MeLeu⁹,Nle¹⁰]-NKA(4-10)