Lopinavir
Tocris Bioscience, part of Bio-Techne | Catalog # 7052
Highly potent and selective HIV-1 protease inhibitor
Key Product Details
Description
Highly potent and selective HIV-1 protease inhibitor
Alternative Names
ABT-378
Product Description
Lopinavir is a highly potent and selective HIV-1 protease inhibitor (IC50 = 6.5 nM, HIV cultured in peripheral blood mononuclear cells; Ki = 1.3 pM). Displays >105-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits HIV-1 protease in patient HIV isolates displaying mutations that confer resistance to ritonavir (Cat. No. 5856) (IC50 values in 5 - 50 nM range). Also inhibits SARS-CoV-2 replication in vitro (IC50 = 26 μM)Product Specifications
Molecular Weight
628.80
Formula
C37H48N4O5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
CAS Number
192725-17-0
PubChem ID
92727
InChI Key
KJHKTHWMRKYKJE-SUGCFTRWSA-N
SMILES
CC([C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@@H](NC(COC2=C(C=CC=C2C)C)=O)CC3=CC=CC=C3)O)=O)N4CCCNC4=O)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.88 | 100 | |
| Ethanol | 62.88 | 100 |
Preparing Stock Solutions
for Lopinavir
The following data is based on the product molecular weight 628.80
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.59 mL | 7.95 mL | 15.90 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
| 10 mM | 0.16 mL | 0.80 mL | 1.59 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.32 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Carrillo In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J.Virol. 1998 PMID: 9696850
- Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 2020 PMID: 32251767
- Sham ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob.Agents Chemother. 1998 PMID: 9835517
Product Specific Notices for Lopinavir
For research use only
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