Ritonavir

Tocris Bioscience, part of Bio-Techne | Catalog # 5856

HIV-1 and HIV-2 protease inhibitor
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Key Product Details

Description

HIV-1 and HIV-2 protease inhibitor

Alternative Names

ABT-538,A-84538,Abbot 84538

View all HIV Protease Inhibitors »

Product Description

Ritonavir is a HIV-1 and HIV-2 protease inhibitor (EC50 values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. When used in combination with lopinavir, improves outcome in an animal model of MERS-CoV infection.

Product Specifications

Molecular Weight

720.94

Formula

C37H48N6O5S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate

CAS Number

155213-67-5

PubChem ID

392622

InChI Key

NCDNCNXCDXHOMX-XGKFQTDJSA-N

SMILES

O[C@@H](C[C@@H](NC([C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.42 20 with gentle warming
Ethanol 7.21 10

Preparing Stock Solutions for Ritonavir

The following data is based on the product molecular weight 720.94

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.94 mL 34.68 mL 69.35 mL
1 mM 1.39 mL 6.94 mL 13.87 mL
2 mM 0.69 mL 3.47 mL 6.94 mL
10 mM 0.14 mL 0.69 mL 1.39 mL

Calculators

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Reconstitution Calculator

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Product Documents for Ritonavir

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ritonavir

For research use only

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