LIH 383

Name: LIH 383
Brand: Tocris Bioscience
SKU: 8095

Tocris Bioscience, part of Bio-Techne | Catalog # 8095

COA / SDS

Atypical chemokine receptor (ACKR3) agonist

Key Product Details

Description:	Atypical chemokine receptor (ACKR3) agonist
Purity:	≥95% (HPLC)
Molecular Weight:	997.23

View Full Technical Details for LIH 383

Technical Data
Citations

Biological Activity for LIH 383

LIH 383 is a potent and highly selective atypical chemokine receptor (ACKR3/CXCR7) agonist. LIH 383 competes directly with CXCL12-AF647 and is more potent in inducing β-arrestin recruitment to ACKR3 (EC₅₀ = 0.61 nM) than the full-length chemokine ligands CXCL12 or CXCL11 (EC₅₀ values are 1.2 nM and 2.2 nM, respectively). In a rat ex vivo model, LIH 383 increases the availability and signaling of opioid peptides at classical receptors.

Licensing Information

Sold under patent license from Luxembourg Institute of Health.

Technical Data for LIH 383

M. Wt	997.23
Formula	C₄₅H₇₂N₁₆O₈S
Single Letter Sequence	FGGFMRRK (Modification: Lys-8 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2866266-58-0
InChi Key	HKVZPBVWPFDBBQ-LBBUGJAGSA-N
Smiles	O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=CC=C2)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for LIH 383

Solubility

Soluble to 2mg/ml in water

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References for LIH 383

References are publications that support the biological activity of the product.

Kleist Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. Science 2022 PMID: 35857540
Meyrath The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides. Nat.Commun. 2020 PMID: 32561830