LDC 000067

Tocris Bioscience, part of Bio-Techne | Catalog # 6752

Potent and selective CDK9 inhibitor
Discontinued Product
6752 has been discontinued. View all Cyclin-dependent Kinase Inhibitors products.

Key Product Details

Description

Potent and selective CDK9 inhibitor

View all Cyclin-dependent Kinase Inhibitors »

Product Description

LDC 000067 is a potent and selective CDK9 inhibitor (IC50 = 44 nM at CDK9-cyclin T1). Inhibits other CDKs in the micromolar range (IC50 values are 2.4, 5.5, 9.2, >10 and >10 μM for CDK2-cyclin A, CDK1-cyclin B1, CDK4-cyclin D1, CDK6-cyclin D3 and CDK7-cyclin H-MAT1, respectively). Inhibits P-TEFb-dependent in vitro transcription. Induces apoptosis in vitro and in vivo in combination with BI 894999.

Product Specifications

Molecular Weight

370.43

Formula

C18H18N4O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

CAS Number

1073485-20-7

PubChem ID

25104564

InChI Key

GGQCIOOSELPMBB-UHFFFAOYSA-N

SMILES

COC1=C(C2=NC=NC(NC3=CC(CS(N)(=O)=O)=CC=C3)=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.04 100

Preparing Stock Solutions for LDC 000067

The following data is based on the product molecular weight 370.43

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.70 mL 13.50 mL 27.00 mL
5 mM 0.54 mL 2.70 mL 5.40 mL
10 mM 0.27 mL 1.35 mL 2.70 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Calculators

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Product Documents for LDC 000067

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for LDC 000067

For research use only

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