Laulimalide

Tocris Bioscience, part of Bio-Techne | Catalog # 4007

Microtubule stabilzing agent
Discontinued Product
4007 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description

Microtubule stabilzing agent

Alternative Names

Fijianolide B

View all Microtubule Binding Compounds »

Product Description

Laulimalide is a microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.

Product Specifications

Molecular Weight

514.65

Formula

C30H42O7

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(1R,3S,7S,8S,10S,12S,15Z,18R)-12-[(1S,2E)-3-[(2S)-3,6-dihydro-4-methyl-2H-pyran-2-yl]-1-hydroxy-2-propen-1-yl]-7-hydroxy-3-methyl-5-methylene-9,13,22-trioxatricyclo[16.3.1.08,10]docosa-15,19-dien-14-one

CAS Number

115268-43-4

PubChem ID

6918457

InChI Key

MSBQEQDLFWWWMV-XZZGLLCESA-N

SMILES

O=C(O[C@H]([C@@H](O)/C=C/[C@]1([H])CC(C)=CCO1)C[C@]2([H])O[C@@]2([H])[C@@H](O)C3)/C=C\C[C@]4([H])C=CC[C@](C[C@@H](C)CC3=C)([H])O4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 10.29 20

Preparing Stock Solutions for Laulimalide

The following data is based on the product molecular weight 514.65

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.72 mL 48.58 mL 97.15 mL
1 mM 1.94 mL 9.72 mL 19.43 mL
2 mM 0.97 mL 4.86 mL 9.72 mL
10 mM 0.19 mL 0.97 mL 1.94 mL

Calculators

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Reconstitution Calculator

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Product Documents for Laulimalide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Laulimalide

For research use only

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