L-DON

Tocris Bioscience, part of Bio-Techne | Catalog # 6809

Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
Discontinued Product
6809 has been discontinued. View all Glutaminase Inhibitors products.

Key Product Details

Description

Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters

View all Glutaminase Inhibitors »

Product Description

L-DON is a glutaminase inhibitor (Ki = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.

Product Specifications

Molecular Weight

171.15

Formula

C6H9N3O3

Storage

Store at -20°C

Chemical Name

6-Diazo-5-oxo-L-norleucine

CAS Number

157-03-9

PubChem ID

9087

InChI Key

YCWQAMGASJSUIP-YFKPBYRVSA-N

SMILES

N[C@H](C(O)=O)CCC(C=[N+]=[N-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 8.56 50

Preparing Stock Solutions for L-DON

The following data is based on the product molecular weight 171.15

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 11.69 mL 58.43 mL 116.86 mL
2.5 mM 2.34 mL 11.69 mL 23.37 mL
5 mM 1.17 mL 5.84 mL 11.69 mL
25 mM 0.23 mL 1.17 mL 2.34 mL

Calculators

Molarity Calculator

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for L-DON

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for L-DON

For research use only

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