L-CCG-l

Name: L-CCG-l
Brand: Tocris Bioscience
SKU: 0333

Tocris Bioscience, part of Bio-Techne | Catalog # 0333

Citations (4)

COA / SDS

Potent group II mGlu agonist

Key Product Details

Description:	Potent group II mGlu agonist
Alternative Names:	(2S,3S,4S)-CCG
Chemical Name:	(2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
Purity:	≥99% (HPLC)
Molecular Weight:	159.14

View Full Technical Details for L-CCG-l

Technical Data
Citations

Biological Activity for L-CCG-l

L-CCG-l is a potent group II metabotropic glutamate receptor agonist. More active than glutamate or (±)-trans-ACPD (Cat. No. 0187).

Technical Data for L-CCG-l

M. Wt	159.14
Formula	C₆H₉NO₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	117857-93-9
PubChem ID	5310956
InChi Key	GZOVEPYOCJWRFC-HZLVTQRSSA-N
Smiles	N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@]1([C@@](O)=O)[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for L-CCG-l

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	1eq. NaOH		100

Preparing Stock Solutions for L-CCG-l

The following data is based on the product molecular weight 159.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	6.28 mL	31.42 mL	62.84 mL
5 mM	1.26 mL	6.28 mL	12.57 mL
10 mM	0.63 mL	3.14 mL	6.28 mL
50 mM	0.13 mL	0.63 mL	1.26 mL

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Reconstitution Calculator

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References for L-CCG-l

References are publications that support the biological activity of the product.

Wright and Schoepp Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus. Eur.J.Pharmacol. 1996 PMID: 8666060
Hayashi Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 1992 PMID: 1330184
Shinozaki Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 1989 PMID: 2692753
Brabet Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 1998 PMID: 9833633