Kainic acid (synthetic)

Name: Kainic acid (synthetic)
Brand: Tocris Bioscience
SKU: 7065

Tocris Bioscience, part of Bio-Techne | Catalog # 7065

Citations (9)

COA / SDS

Kainate agonist; excitant and neurotoxin

Key Product Details

Description:	Kainate agonist; excitant and neurotoxin
Chemical Name:	(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	213.23

View Full Technical Details for Kainic acid (synthetic)

Technical Data
Citations

Biological Activity for Kainic acid (synthetic)

Kainic acid, also known as kainate, is a selective agonist of kainate ionotropic glutamate receptors (EC₅₀ = 0.6 μM - 7.4 μM) and a partial agonist at AMPA receptors (EC₅₀ = 31 μM - 170 μM). Kainic acid is used to model epilepsy in vivo and to study the mechanisms of neurodegeneration and neurocytosis induced by excess stimulation by kainic acid. Kainate is shown to be involved in amyloidogenic processing of amyloid precursor protein and Aβ peptides in Alzheimer's. Synthetic version of Kainic acid (Cat. No. 0222)

Related compounds include the kainate receptor agonist Domoic acid (Cat. No. 0269) and the antagonist NBQX (Cat. No. 0373).

Technical Data for Kainic acid (synthetic)

M. Wt	213.23
Formula	C₁₀H₁₅NO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	487-79-6
PubChem ID	10255
InChi Key	VLSMHEGGTFMBBZ-OOZYFLPDSA-N
Smiles	C=C(C)[C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Kainic acid (synthetic)

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	5.33	25

Preparing Stock Solutions for Kainic acid (synthetic)

The following data is based on the product molecular weight 213.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	18.76 mL	93.80 mL	187.59 mL
1.25 mM	3.75 mL	18.76 mL	37.52 mL
2.5 mM	1.88 mL	9.38 mL	18.76 mL
12.5 mM	0.38 mL	1.88 mL	3.75 mL

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References for Kainic acid (synthetic)

References are publications that support the biological activity of the product.

Watkins Excitatory amino acids. Kainic acid as a Tool in Neurobiology. Edited by E
Watkins & Evans Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 1981 PMID: 6112965