Domoic acid
Tocris Bioscience, part of Bio-Techne | Catalog # 0269
Potent and selective kainate agonist
Discontinued Product
0269 has been discontinued.
View all Kainate Receptor Agonists products.
Key Product Details
Description
Potent and selective kainate agonist
Product Description
Domoic acid is a kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.Product Specifications
Molecular Weight
311.33
Formula
C15H21NO6
Storage
Desiccate at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
CAS Number
14277-97-5
PubChem ID
5282253
InChI Key
VZFRNCSOCOPNDB-AOKDLOFSSA-N
SMILES
[H][C@](C)([C@](O)=O)/C=C/C=[C@@](C)\[C@H]1CN[C@H]([C@@](O)=O)[C@H]1CC(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.57 | 50 |
Preparing Stock Solutions
for Domoic acid
The following data is based on the product molecular weight 311.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.42 mL | 32.12 mL | 64.24 mL |
| 2.5 mM | 1.28 mL | 6.42 mL | 12.85 mL |
| 5 mM | 0.64 mL | 3.21 mL | 6.42 mL |
| 25 mM | 0.13 mL | 0.64 mL | 1.28 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hampson and Manalo The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 1998 PMID: 10223631
- Debonnel Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 1989 PMID: 2540893
- Watkins Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed
- Agrawal and Evans The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 1986 PMID: 3513882
Product Specific Notices for Domoic acid
For research use only
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