K-252c

Name: K-252c
Brand: Tocris Bioscience
SKU: 2287

Tocris Bioscience, part of Bio-Techne | Catalog # 2287

Citations (2)

COA / SDS

Protein kinase C inhibitor

Discontinued Product

2287 has been discontinued. View all Protein Kinase C Inhibitors products.

Key Product Details

Description:	Protein kinase C inhibitor
Alternative Names:	Staurosporinone
Chemical Name:	6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Purity:	≥99% (HPLC)
Molecular Weight:	311.34

View Full Technical Details for K-252c

Technical Data
Citations

Biological Activity for K-252c

K-252c is an inhibitor of protein kinase C (IC₅₀ = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC₅₀ = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC₅₀ values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC₅₀ values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).

Technical Data for K-252c

M. Wt	311.34
Formula	C₂₀H₁₃N₃O
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	85753-43-1
PubChem ID	3815
InChi Key	MEXUTNIFSHFQRG-UHFFFAOYSA-N
Smiles	O=C(NC3)C1=C3C(C4=CC=CC=C4N5)=C5C2=C1C6=C(C=CC=C6)N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for K-252c

References are publications that support the biological activity of the product.

Zimmermann Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 2000 PMID: 11080540
McGovern and Shoichet Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 2003 PMID: 12672248
Fabre Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1993 PMID: 8081852

K-252c

Tocris Bioscience, part of Bio-Techne | Catalog # 2287

Key Product Details

Biological Activity for K-252c

Technical Data for K-252c

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for K-252c

Product Documents for K-252c

COA

Certificate of Analysis

SDS

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