JNJ 5207852 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4020

High affinity H3 antagonist
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Key Product Details

Description

High affinity H3 antagonist

View all Histamine H3 Receptor Antagonists »

Product Description

JNJ 5207852 dihydrochloride is a high affinity histamine H3 receptor neutral antagonist (pKi values are 8.9 and 9.2 in rat and human respectively). Brain penetrant and orally active. Has 3- and 100-fold higher affinity than thioperamide (Cat. No. 0644) for rat and human H3 receptors respectively. Suppresses slow-wave sleep; exhibits wake-promoting effects in rodent arousal models.

Licensing Information

Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.

Product Specifications

Molecular Weight

389.40

Formula

C20H32N2O.2HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-[3-[4-(1-Piperidinylmethyl)phenoxy]propyl]piperidine hydrochloride

CAS Number

1782228-76-5

PubChem ID

90488903

InChI Key

RLLXSVVZCGBIJR-UHFFFAOYSA-N

SMILES

C1(CN2CCCCC2)=CC=C(OCCCN3CCCCC3)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.47 50
DMSO 7.79 20 with gentle warming

Preparing Stock Solutions for JNJ 5207852 dihydrochloride

The following data is based on the product molecular weight 389.40

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.14 mL 25.68 mL 51.36 mL
2.5 mM 1.03 mL 5.14 mL 10.27 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
25 mM 0.10 mL 0.51 mL 1.03 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for JNJ 5207852 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for JNJ 5207852 dihydrochloride

For research use only

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