JJKK 048

Name: JJKK 048
Brand: Tocris Bioscience
SKU: 5206

Tocris Bioscience, part of Bio-Techne | Catalog # 5206

Citations (2)

COA / SDS

Potent and selective MAGL inhibitor

Key Product Details

Description:	Potent and selective MAGL inhibitor
Chemical Name:	4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone
Purity:	≥98% (HPLC)
Molecular Weight:	434.44

View Full Technical Details for JJKK 048

Technical Data
Citations

Biological Activity for JJKK 048

JJKK 048 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC₅₀ = 0.4 nM). Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6, respectively. Increases brain levels of 2-arachidonoylglycerol (2-AG) levels in mice in vivo. Promotes analgesia in pain models.

Compound Libraries for JJKK 048

JJKK 048 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for JJKK 048

M. Wt	434.44
Formula	C₂₃H₂₂N₄O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1515855-97-6
PubChem ID	76313567
InChi Key	CLSNATLUIXZPMV-UHFFFAOYSA-N
Smiles	O=C(N6C=NC=N6)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)C1=CC(OCO4)=C4C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for JJKK 048

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.44	100

Preparing Stock Solutions for JJKK 048

The following data is based on the product molecular weight 434.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.51 mL	23.02 mL
5 mM	0.46 mL	2.30 mL	4.60 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for JJKK 048

References are publications that support the biological activity of the product.

Laitinen Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol.Pharmacol. 2014 PMID: 24368842
Aaltonen In vivo characterization of the ultrapotent monoacylglycerol lipaseiInhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). J.Pharmacol.Exp.Ther. 2016 PMID: 27451409
Aaltonen Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem.Biol. 2013 PMID: 23521796