JJKK 048

Name: JJKK 048
Brand: Tocris Bioscience
SKU: 5206

Tocris Bioscience, part of Bio-Techne | Catalog # 5206

Citations (2)

COA / SDS

Potent and selective MAGL inhibitor

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Technical Data
Citations

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent and selective MAGL inhibitor

View all Monoacylglycerol Lipase Inhibitors »

Product Description

JJKK 048 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC₅₀ = 0.4 nM). Exhibits >13,000 and ~630-fold selectivity for MAGL over FAAH and ABHD6, respectively. Increases brain levels of 2-arachidonoylglycerol (2-AG) levels in mice in vivo. Promotes analgesia in pain models.

Product Specifications

Molecular Weight

434.44

Formula

C₂₃H₂₂N₄O₅

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone

CAS Number

1515855-97-6

PubChem ID

76313567

InChI Key

CLSNATLUIXZPMV-UHFFFAOYSA-N

SMILES

O=C(N6C=NC=N6)N(CC5)CCC5C(C2=CC=C(OCO3)C3=C2)C1=CC(OCO4)=C4C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.44	100

Preparing Stock Solutions for JJKK 048

The following data is based on the product molecular weight 434.44

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.51 mL	23.02 mL
5 mM	0.46 mL	2.30 mL	4.60 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Laitinen Mutation of Cys242 of human monoacylglycerol lipase disrupts balanced hydrolysis of 1- and 2-monoacylglycerols and selectively impairs inhibitor potency. Mol.Pharmacol. 2014 PMID: 24368842
Aaltonen In vivo characterization of the ultrapotent monoacylglycerol lipaseiInhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048). J.Pharmacol.Exp.Ther. 2016 PMID: 27451409
Aaltonen Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem.Biol. 2013 PMID: 23521796