JHU 37160

Product Description

JHU 37160 is a high affinity and highly potent activator of hM₃D_q and hM₄D_i DREADDs (K_i values are 1.9 nM and 3.6 nM for hM₃D_q and hM₄D_i in vitro, respectively; EC₅₀ values are 0.2 nM and 18.5 nM for hM₄D_i and hM₃D_q in vitro, respectively). Displays approximately 25-fold higher affinity for hM₄D_i compared to DREADD agonist 21 (Cat. No. 5548). Selectively displaces [³H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM₃D_q and hM₄D_i in D₁-expressing neurons, and increases hM₃D_q-stimulated locomotion in rats expressing hM₃D_q in TH-expressing neurons. Brain penetrant in mice, rats and non-human primates.

Solubility

Preparing Stock Solutions for JHU 37160

The following data is based on the product molecular weight 358.85

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.57 mL	27.87 mL	55.73 mL
2.5 mM	1.11 mL	5.57 mL	11.15 mL
5 mM	0.56 mL	2.79 mL	5.57 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bonaventura High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat.Commun. 2019 PMID: 31604917