DREADD agonist 21
Tocris Bioscience, part of Bio-Techne | Catalog # 5548
Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Key Product Details
Description
Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
Alternative Names
Compound 21,C21
Product Description
DREADD agonist 21 is a potent muscarinic DREADD agonist (pEC50 values are 8.91, 8.48 and 7.77 for hM1Dq, hM3Dq and hM4Di in vitro, respectively). Exhibits > 10-fold higher affinity for hM1Dq and hM4Di compared to wild type receptors. Also displays little to no activity at wild type M3 receptors. Activates neurons expressing hM3Dq DREADDS and inhibits activity in neurons expressing hM4Di in vivo. Displays excellent brain permeability. Water soluble salt also available, DREADD agonist 21 hydrochloride (Cat. No. 6422).Product Specifications
Molecular Weight
278.35
Formula
C17H18N4
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
CAS Number
56296-18-5
PubChem ID
11818276
InChI Key
JCBYXNSOLUVGTF-UHFFFAOYSA-N
SMILES
C1(N4CCNCC4)=NC(C=CC=C3)=C3NC2=C1C=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.84 | 100 | |
| Ethanol | 27.84 | 100 |
Preparing Stock Solutions
for DREADD agonist 21
The following data is based on the product molecular weight 278.35
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.59 mL | 17.96 mL | 35.93 mL |
| 5 mM | 0.72 mL | 3.59 mL | 7.19 mL |
| 10 mM | 0.36 mL | 1.80 mL | 3.59 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Thompson DREADD agonist 21 (C21) is an effective agonist for muscarinic-based DREADDs in vitro and in vivo. ACS Pharmacol.Transl.Sci. 2018 PMID: 30868140
- Chen The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 2015 PMID: 25587888
Product Specific Notices for DREADD agonist 21
For research use only
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