DREADD agonist 21 dihydrochloride

Name: DREADD agonist 21 dihydrochloride
Brand: Tocris Bioscience
SKU: 6422

Tocris Bioscience, part of Bio-Techne | Catalog # 6422

Citations (24)

COA / SDS

Potent hM3Dq and hM4Di DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)

Key Product Details

Description:	Potent hM₃D_q and hM₄D_i DREADD agonist; water soluble version of DREADD agonist 21 (Cat. No. 5548)
Alternative Names:	Compound 21 (water-soluble)
Chemical Name:	11-(1-Piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	351.27

View Full Technical Details for DREADD agonist 21 dihydrochloride

Technical Data
Citations

Biological Activity for DREADD agonist 21 dihydrochloride

DREADD agonist 21 dihydrochloride is a water soluble version of DREADD agonist 21 (Cat. No. 5548). Potent muscarinic DREADD agonist.

Compound Libraries for DREADD agonist 21 dihydrochloride

DREADD agonist 21 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DREADD agonist 21 dihydrochloride

M. Wt	351.27
Formula	C₁₇H₁₈N₄.2HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	2250025-92-2
PubChem ID	134812837
InChi Key	SETCOPAXYQJWKI-UHFFFAOYSA-N
Smiles	C1(N2CCNCC2)=NC(C=CC=C3)=C3NC4=C1C=CC=C4.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for DREADD agonist 21 dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	35.13	100
	DMSO	35.13	100

Preparing Stock Solutions for DREADD agonist 21 dihydrochloride

The following data is based on the product molecular weight 351.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.47 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for DREADD agonist 21 dihydrochloride

References are publications that support the biological activity of the product.

Chen The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem.Neurosci. 2015 PMID: 25587888