INF 4E

Name: INF 4E
Brand: Tocris Bioscience
SKU: 6172
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6172

(1)

Citations (2)

COA / SDS

Caspase-1 and NLRP3 inflammasome inhibitor

Key Product Details

Description:	Caspase-1 and NLRP3 inflammasome inhibitor
Chemical Name:	Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate
Purity:	≥98% (HPLC)
Molecular Weight:	240.68

View Full Technical Details for INF 4E

Technical Data
Citations / Reviews (1)

Biological Activity for INF 4E

INF 4E is a NLRP3 inflammasome and caspase-1 inhibitor (K_i = 9.6 μM for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

Technical Data for INF 4E

M. Wt	240.68
Formula	C₁₂H₁₃ClO₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	88039-46-7
PubChem ID	11402215
InChi Key	BSRPDXCMAOIUOO-UHFFFAOYSA-N
Smiles	CCOC(C(C(C1=C(C=CC=C1)Cl)O)=C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for INF 4E

Solubility

Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml)

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References for INF 4E

References are publications that support the biological activity of the product.

Cocco Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J.Med.Chem. 2014 PMID: 25418070