Iloprost is a prostacyclin (PGI₂) analog that binds with high affinity to IP, EP₁ and EP₃ receptors (K_i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP₁, EP₃, EP₄, FP, DP, EP₂ and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC₅₀ values are 0.24, 0.71 and 1.07 nM respectively).

Product Specifications

Molecular Weight

360.49

Formula

C₂₂H₃₂O₄

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid

CAS Number

78919-13-8

PubChem ID

5311181

InChI Key

HIFJCPQKFCZDDL-ACWOEMLNSA-N

SMILES

O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)

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Background References

References are publications that support the biological activity of the product.

Abramovitz The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 2000 PMID: 10634944
Schror The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI₂ in vitro. Naunyn-Schmied.Arch.Pharmacol.
Della Bella Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 2001 PMID: 11403500

Iloprost

Tocris Bioscience, part of Bio-Techne | Catalog # 2038

Key Product Details

Description

Alternative Names

View all Prostanoid Receptor Agonists »

Product Description