IHR 1
Tocris Bioscience, part of Bio-Techne | Catalog # 5554
Potent Smo antagonist
Product Description
IHR 1 is a potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.Fluorescent Analog also available.
Product Specifications
Molecular Weight
454.13
Formula
C20H12Cl4N2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]
CAS Number
548779-60-8
PubChem ID
2167042
InChI Key
VCLHHRGZKNUOAQ-UHFFFAOYSA-N
SMILES
ClC1=CC(C(NC2=CC=C(NC(C3=C(Cl)C=CC(Cl)=C3)=O)C=C2)=O)=C(Cl)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.08 | 20 with gentle warming |
Preparing Stock Solutions
for IHR 1
The following data is based on the product molecular weight 454.13
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.01 mL | 55.05 mL | 110.10 mL |
| 1 mM | 2.20 mL | 11.01 mL | 22.02 mL |
| 2 mM | 1.10 mL | 5.51 mL | 11.01 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.20 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fan The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 2014 PMID: 25484239
Product Specific Notices for IHR 1
For research use only
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