IHR-Cy3
Tocris Bioscience, part of Bio-Techne | Catalog # 5561
Potent fluorescent Smo antagonist
Discontinued Product
5561 has been discontinued.
View all Smoothened Receptor Antagonists products.
Key Product Details
Description
Potent fluorescent Smo antagonist
Product Description
IHR-Cy3 is a potent fluorescent Smo antagonist (IC50 = 100 nM).Non-fluorescent analog also available.
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Product Specifications
Molecular Weight
1174.64
Formula
C58H63Cl3N6O10S2
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
(2-[3-[1-(6-[[7-[[4-Chloro-3-[[4-(2,5-dichlorobenzamido)phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1,3-dihydro-3,3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3,3-dimethyl-5-sulfo-3H-indolium, inner salt
PubChem ID
122705984
InChI Key
KBLRMHCNXCHIQG-UHFFFAOYSA-N
SMILES
ClC1=CC=C(Cl)C(C(NC2=CC=C(NC(C3=C(Cl)C=CC(NC(CCCCCCNC(CCCCC[N+]4=C(/C=C/C=C5N(CC)C(C=CC(S(=O)([O-])=O)=C6)=C6C/5(C)C)C(C)(C)C7=C4C=CC(S(=O)(O)=O)=C7)=O)=O)=C3)=O)C=C2)=O)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.87 | 5 |
Preparing Stock Solutions
for IHR-Cy3
The following data is based on the product molecular weight 1174.64
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 17.03 mL | 85.13 mL | 170.26 mL |
| 0.25 mM | 3.41 mL | 17.03 mL | 34.05 mL |
| 0.5 mM | 1.70 mL | 8.51 mL | 17.03 mL |
| 2.5 mM | 0.34 mL | 1.70 mL | 3.41 mL |
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Background References
References are publications that support the biological activity of the product.
- Fan The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 2014 PMID: 25484239
Product Specific Notices for IHR-Cy3
For research use only
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