I-BRD9
Tocris Bioscience, part of Bio-Techne | Catalog # 5591
Potent and selective BRD9 inhibitor
Key Product Details
Description
Potent and selective BRD9 inhibitor
Product Description
I-BRD9 is a potent and selective BRD9 inhibitor (pIC50 = 7.3). Exhibits >70-fold selectivity for BRD9 over a panel of 34 other bromodomains and >700-fold selectivity over the BET family. Downregulates CLEC1, DUSP6, FES and SAMSN1 genes in Kasumi-1 cells.Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the I-BRD9 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of I-BRD9 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
497.55
Formula
C22H22F3N3O3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
CAS Number
1714146-59-4
PubChem ID
91668541
InChI Key
WRUWGLUCNBMGPS-UHFFFAOYSA-N
SMILES
O=C1C2=C(SC(C(NC3CCS(CC3)(=O)=O)=N)=C2)C(C4=CC=CC(C(F)(F)F)=C4)=CN1CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.76 | 100 |
Preparing Stock Solutions
for I-BRD9
The following data is based on the product molecular weight 497.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.01 mL | 10.05 mL | 20.10 mL |
| 5 mM | 0.40 mL | 2.01 mL | 4.02 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.01 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Theodoulou Discovery of I-BRD9, a selective cell active chemical probe for bromodomain containing protein 9 inhibition. J.Med.Chem 2015 PMID: 25856009
Product Specific Notices for I-BRD9
For research use only
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