HLM 006474

Tocris Bioscience, part of Bio-Techne | Catalog # 5283

E2F transcription factor inhibitor
Discontinued Product
5283 has been discontinued. View all Additional Transcription Factor Compounds products.

Key Product Details

Description

E2F transcription factor inhibitor

View all Additional Transcription Factor Compounds »

Product Description

HLM 006474 is an E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

Product Specifications

Molecular Weight

399.48

Formula

C25H25N3O2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol

CAS Number

353519-63-8

PubChem ID

2895500

InChI Key

CYNZBLNMIJNBSF-UHFFFAOYSA-N

SMILES

CC1=C(OCC)C=CC(C(C3=C(O)C(N=C(C)C=C4)=C4C=C3)NC2=NC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.99 20

Preparing Stock Solutions for HLM 006474

The following data is based on the product molecular weight 399.48

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.52 mL 62.58 mL 125.16 mL
1 mM 2.50 mL 12.52 mL 25.03 mL
2 mM 1.25 mL 6.26 mL 12.52 mL
10 mM 0.25 mL 1.25 mL 2.50 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for HLM 006474

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for HLM 006474

For research use only

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