Hispidulin

Product Description

Hispidulin is a partial positive allosteric modulator at the benzodiazepine receptor (IC₅₀ = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABA_A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

Solubility

Preparing Stock Solutions for Hispidulin

The following data is based on the product molecular weight 300.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	13.32 mL	66.61 mL	133.21 mL
1.25 mM	2.66 mL	13.32 mL	26.64 mL
2.5 mM	1.33 mL	6.66 mL	13.32 mL
12.5 mM	0.27 mL	1.33 mL	2.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kavvadias Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003 PMID: 12624814
• Kavvadias The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br.J.Pharmacol. 2004 PMID: 15231642
• Bourdillat Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur.J.Pharmacol. 1988 PMID: 2836213